Searchable abstracts of presentations at key conferences in endocrinology

ea0087p4 | Poster Presentations | UKINETS2022

Exploring the potential benefit of epigenetic modification: The LANTana trial, an open label, single arm, phase Ib study to evaluate the effect of pre-treatment with ASTX727 (a demethylating agent) followed by Lutathera (177Lu-DOTATATE) in patients with progressive, metastatic neuroendocrine tumours (NETs)

Murphy Ravindhi , Chander Gurvin , Sharma Rohini

Background: Neuroendocrine tumours (NET) are rare cancers arising from cells of the neuroendocrine system and frequently present with advanced disease. They are characterised by the presence of somatostatin receptors (SSTR) on the tumour surface. The presence of SSTR are associated with the inhibition of NET proliferation and have formed the basis of peptide receptor radionuclide therapy (PRRT), such as Lutathera. PRRT relies on SSTR tumour expression and patients without this...